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Recent Findings Animal studies raise concern for fetal loss, malformations and adverse fetal growth after GLP-1RA exposure
Practical harm-reduction steps include drinking with a full meal (slows absorption and reduces nausea), spacing drinks 23 hours apart, and alternating each alcoholic drink with 12 oz of water to combat dehydration
Other concerning risks include intestinal blockages, pancreatitis, and rare but severe gallbladder complications such as cholecystitis (inflammation)
On the other hand, more aggressive treatment to goal A1C levels closer to 6% may be beneficial in diabetics with long life expectancy and in whom the benefits of more intensive treatment are expected to outweigh the risks